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Ntegrin) (CD209) on dendritic cells [17-19]. Dendritic cells are considered crucial to fighting viral infections because of their ability to acquire and display viral antigens that would otherwisePage 2 of(page number not for citation purposes)Virology Journal 2009, 6:http://www.virologyj.com/content/6/1/evade the immune system. Dendritic cells affect the dengue virus in two ways. Immature dendrit
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Combine to form a C5 convertase. Runaway complement activation is prevented by binding of Complement Receptor 1 (CR1) and a constitutively active membrane bound Decay Accelerating Factor (DAF, or CD55) which can prevent the complement cascade[51]. In patients with severe dengue, large amounts of C3a have been detected revealing a role for complement in dengue pathogenesis. This finding might be an
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Er positive cells were stained with Ki67, they show definitive proliferation. The cells are also found to be 'massively' apoptotic as determined by TUNEL staining. The balance of apoptotic cells with proliferative cells may skew T cell responses toward a crossreactive phenotype. When looking at the specific T-cells involved in secondary infections with DENV1, many of the T-cells show a preference
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Issecting the earliest evolutionary steps in the emergence of HIV-1M. Keywords: HIV-1 diversity, West central Africa, RDP3, Maximum likelihood, PHYMLFindings The Congo basin in west central Africa is thought to be the origin of HIV, where several cross-species transmission events from chimpanzees to humans occurred [1,2]. Cameroon, located in this region, has one of the most genetically diverse HI
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Ntegrin) (CD209) on dendritic cells [17-19]. Dendritic cells are considered crucial to fighting viral infections because of their ability to acquire and display viral antigens that would otherwisePage 2 of(page number not for citation purposes)Virology Journal 2009, 6:http://www.virologyj.com/content/6/1/evade the immune system. Dendritic cells affect the dengue virus in two ways. Immature dendrit
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Helial cells, smooth muscles cells, and activated T-cells, but, interestingly, not na e T-cells. C5aR also activates a number of downstream signaling pathways including PI3K- (Phosophoinosital -3 Kinase), PLC (Phospholipase C), PLD (Phospholipase D), Raf and WASP (Wiskott-Aldrich syndrome protein). As a key modulator of the immune system, complement derived proteins clearly have the capacity to af
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Cias Zembe1, Eitel Mpoudi-Ngole2, Carolyn Williamson1,4 and Wendy A Burgers1*AbstractBackground: Cameroon, in west central Africa, has an extraordinary degree of HIV diversity, presenting a major challenge for the development of an effective HIV vaccine. Given the continuing need to closely monitor the emergence of new HIV variants in the country, we analyzed HIV-1 genetic diversity in 59 plasma s

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