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Athione S -transferase activity, and lipid peroxidation was observed in liver and brain. Exposure to toluene, one of the gasoline constituents, both in vivo and in vitro, leads to reactive oxygen species formation in many tissues including brain tissue [36-38]. The study of Calder -Guzm et al [39] revealed that the aldehydes resulting from the oxidation of the methyl groups in the aromatic compou
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Ed as means ?SD a: significantly different from the control group. b: significantly different from the leaded gasoline. Asterisks indicate the level of significance (* P
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N male rats.Parameter Duration of aggression/sec GROUP Control Leaded gasoline Unleaded gasoline Tooth chattering 0.9 ?0.23 4.7 ?1.1 a** 4.4 ?0.92 a* Threat posture 1.5 ?0.54 6 ?1.2 a* 6.2 ?1.31 a* Leaping and biting 1.9 ?0.72 5.5 ?1.45 5.9 ?1.50 Boxing position 1 ?0.42 2.2 ?0.63 2.2 ?0.Values are expressed as means ?SE a: significantly different from the control group. Asterisks indicate the leve
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Ive behaviour in male rats.Parameter GROUP Tooth chattering Control Leaded gasoline Unleaded gasoline 1.2 ?0.33 3.7 ?0.63 a* 4 ?0.87 a* Number of aggression events Threat posture 1.1 ?0.31 3.9 ?0.43 a** 3.6 ?0.87 a* Leaping and biting 0.9 ?0.35 3.7 ?0.58 a** 3.4 ?0.70 a* Boxing position 0.8 ?0.25 2.7 ?0.47 a* 3.2 ?0.74 a**Values are expressed as means ?SE a: significantly different from the contro
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N male rats.Parameter Duration of aggression/sec GROUP Control Leaded gasoline Unleaded gasoline Tooth chattering 0.9 ?0.23 4.7 ?1.1 a** 4.4 ?0.92 a* Threat posture 1.5 ?0.54 6 ?1.2 a* 6.2 ?1.31 a* Leaping and biting 1.9 ?0.72 5.5 ?1.45 5.9 ?1.50 Boxing position 1 ?0.42 2.2 ?0.63 2.2 ?0.Values are expressed as means ?SE a: significantly different from the control group. Asterisks indicate the leve
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D that volatile solvents such as benzene, a main constituent of gasoline fuel, seems to interact with the synthesis and catabolism of catecholamines and serotonin in the brain, which might explain the neurotoxic effects of these solvents [53]. In this regard, deficiencies of serotonin or other monoamine neurotransmitters such as dopamine and norepinephrine are linked with depression [54,55]. In re