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Ecules or to relative reduction in acetylcholinesterase-containing neurons, thus potentiating cholinergic effects. In the present study, no statistical differences were detected among the serotonin levels of the cerebral cortex in the three groups; the control, the leaded and the unleaded. However, in the hypothalamus, hippocampus, cerebellum, the serotonin level was lower in the groups exposed to
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Athione S -transferase activity, and lipid peroxidation was observed in liver and brain. Exposure to toluene, one of the gasoline constituents, both in vivo and in vitro, leads to reactive oxygen species formation in many tissues including brain tissue [36-38]. The study of Calder -Guzm et al [39] revealed that the aldehydes resulting from the oxidation of the methyl groups in the aromatic compou
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N male rats.Parameter Duration of aggression/sec GROUP Control Leaded gasoline Unleaded gasoline Tooth chattering 0.9 ?0.23 4.7 ?1.1 a** 4.4 ?0.92 a* Threat posture 1.5 ?0.54 6 ?1.2 a* 6.2 ?1.31 a* Leaping and biting 1.9 ?0.72 5.5 ?1.45 5.9 ?1.50 Boxing position 1 ?0.42 2.2 ?0.63 2.2 ?0.Values are expressed as means ?SE a: significantly different from the control group. Asterisks indicate the leve
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Is the study of Gutteridge and Halliwell [44] showing that Na+, K+-ATPase reduces its activity up to 50 due to oxidative stress. The present findings show that the rats exhibited a decrease in the activity of AChE in the unleaded group in comparison with either the control or the leaded groups. In addition to its function in degrading acetylcholine and modulation of neural function; AChE as a str
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Nnervations reaches out to the hypothalamus to regulate secretion of TRH and prolactin secretion, and then projects to the brain limbic system to modulate motivations and emotions [47]. So, gasoline induced impairment of the DA system would result in serious impacts on the neural control of voluntary locomotion and would affect several behavioural aspects.In the present study, the norepinephrine l
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Ial indicate that Na+, K+-ATPase activity and total protein content in the leaded or unleaded gasoline groups were lower than those of the control group. The inhibition of the plasma membrane Na+, K+-ATPase might have been attributed to a direct effect of the solvents and alcohols in the gasoline on the membrane causing dissolving the its bilayers. The most outstanding are toluene (highly lipophyl
1
Ial indicate that Na+, K+-ATPase activity and total protein content in the leaded or unleaded gasoline groups were lower than those of the control group. The inhibition of the plasma membrane Na+, K+-ATPase might have been attributed to a direct effect of the solvents and alcohols in the gasoline on the membrane causing dissolving the its bilayers. The most outstanding are toluene (highly lipophyl